Senate Republicans can afford to lose no more than three of their own votes on the bill, but two already are opposed and others remained undecided.

WASHINGTON (AP) — After a weekend of setbacks, the Senate will try to sprint ahead Monday on President Donald Trump’s big bill of tax breaks and spending cuts despite a series of challenges, including the sudden announcement from one GOP senator that he won’t run for reelection after opposing the package over its Medicaid health care cuts.