DNA polymerase ζ (Polζ) has emerged as a key reverse transcriptase in RNA-templated double-strand break repair (RT-DSBR), beyond its canonical role in translesion DNA synthesis (TLS). We present here ...

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

Cancer cells are characterized by the presence of oncogene-induced DNA replication stress. A common consequence of replication stress is failure to complete DNA replication in S-phase, in which case, ...

Department of Biomolecular Engineering, Baskin School of Engineering,University of California, Santa Cruz. Biological nanopores can be used to examine the composition and structure of single DNA ...

A team led by Professor Michal Hocek at IOCB Prague has explored the limits of the structure and function of DNA and successfully pushed forward known boundaries. Their latest research has just been ...

Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

When DNA is damaged, cellular processes respond and repair the DNA. Inhibiting DNA damage repair can be therapeutically ...

Biomolecular nanomachines, such as enzymes and molecular motors, are the workhorses behind the synthesis and organization of complex materials in life. Powered by chemical energy, they build, ...