If you're a road-tripper whose heart jumps at "historic district" signs, or you simply can't resist a dusty Main Street with charming structures — then Highway 395 in California is calling your name.

HGTV has named California's U.S. 395 east of Stockton in the Sierra as one of the most popular road trips in the United States, and fall is a spectacular time to take in its breathtaking beauty and ...