Structural, functional and computational evidence demonstrates that when certain ion channels are activated by mechanical force, they assume an open configuration in which the pore is formed by both ...

Pharmaceutical scientists and biologists are teaming up to make the next generation of lipid nanoparticles (LNPs) for drug delivery. Combining structural biology with cutting edge pharmaceutical ...

Scientists have found that 93% of the lipids in brain tissue are distributed differently in the white and gray matter, the subcortex, the visual and motor cortices, and the prefrontal cortex, which is ...

In humans, virtually every cell stores fat. However, patients with a rare condition called congenital lipodystrophy, which is often diagnosed in childhood, cannot properly store fat, which accumulates ...

The nuclear envelope (NE) is a dynamic and selective barrier that organizes genome function and nucleocytoplasmic ...

Mitochondria are the powerhouse of cells which continuously convert energy from food into the chemical energy currency called ATP. This essential process depends on large protein complexes within the ...

A research team led by Daniel Lietha has just published in The EMBO Journal the mechanistic details of the activation of the Focal Adhesion Kinase (FAK) on lipid membranes. Lietha started this ...

The cytokine-producing signal protein, a target for drug hunters, has additional activators that could be manipulated ...

Eight young (25.5 ± 1.0 years), healthy men were studied. They were lean (weight 76.4 ± 4.0 kg; BMI 25.4 ± 1.0 kg/m 2) and without any family history of diabetes. The study was approved by the Ethical ...