We applied the principle of synthetic lethality to discover a novel strategy for cancer treatment for patients with BRCA1 or ...

We transformed care for advanced prostate cancer, by validating inhibitors of androgen production as an effective cancer ...

PI3 kinase is a lipid signalling enzyme which plays a key role in the development and progression of many cancers as a result ...

We played a major role in revealing the biochemical steps of the RAS-RAF-MAP kinase pathway. We identified one of the major ...

We were the first in Europe to develop chemotherapeutic agents. We discovered, and with The Royal Marsden developed, the chemotherapy drugs busulfan, chlorambucil, melphalan and carboplatin, which are ...

We provided the first conclusive evidence that the basic cause of cancer is damage to DNA. The discovery changed scientific opinion dramatically and marked a turning point for cancer research.

We pioneered the application of evolutionary biology to cancer and established cancer stem cells as the units of natural selection.

Through studies that were amongst the largest of their kind, we identified several genes involved in breast and/or ovarian cancer predisposition such as CHEK2, BRIP1, ATM, PALB2, RAD51C and RAD51D.

We identified many of the cancer-causing chemicals in cigarette smoke and coal tar – including the first pure carcinogen ever to be isolated.

We led major clinical trials in radiotherapy and imaging which have changed standard clinical practice for cancer treatment.

We identified the breast cancer gene BRCA2, which enabled families with a history of breast cancer to be assessed for future risk, and laid the groundwork for developing novel forms of therapy for ...

We played a major role in characterising the BRAF gene and its role in cancer, increasing our understanding of malignant melanoma.