Background: Double-stranded DNA breaks (DSBs) in human cells are typically repaired via nonhomologous end joining (NHEJ) or homologous recombination (HR). Deficiency of HR-mediated DNA repair plays a ...

Standard spatial proteomics (SP) pipelines for biomarker discovery have traditionally relied on cell segmentation followed by single-marker thresholding or rule-based mechanisms to assign cell ...

Cancer Res (2023) 83 (8_Supplement): LB031. Citation Format: Ting Zhang, Lingfeng You, Jianyan Xu, Junzhao Yin, Bolei Qu, Yuchang Mao, Beibei Fu, Dan Cao, Linda Zhao, Jun Feng, Min Hu, Feng He.

In 1978, a Cancer Research article by Dougherty and colleagues reported the first large-scale clinical trial of photodynamic therapy (PDT) for treatment of 113 cutaneous or subcutaneous lesions ...

Abstract:. New research suggests that starting a glucagon-like–peptide (GLP)-1 receptor agonist following a diagnosis of certain obesity-related cancers—namely stage I, II, or III lung, breast, ...

Background: Despite a high response rate to cCRT, patients with limited-stage SCLC generally experience recurrence of disease after a few months and survival remains poor. Immunotherapy has shown ...

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Cancer Res (2024) 84 (7_Supplement): LB100. Background: A multi-analyte blood test has potential for robust sensitivity in detecting a broad range of cancer types and stages. Previously, using ...

Background: While doublet therapies provide important first-line treatment options in metastatic renal cell carcinoma (mRCC), novel and mechanistically distinct agents are needed for pts who are not ...

Cancer Res (2025) 85 (8_Supplement_2): CT215. SDHd GIST is defined by alterations in an SDH complex subunit gene or SDHC promotor methylation leading to genome-wide DNA hypermethylation. Recent ...

Rapid and efficient isolation of antigen-specific B cells is a critical bottleneck during antibody discovery, especially for antigens that are complex, maintain small and specific epitopes, or have a ...

Cancer-associated fibroblasts (CAFs) are key contributors to promote cancer progression in the lung tumor microenvironment via interactions with cancer cells and other cell types. In a 3-D culture ...