The San Francisco 49ers had three defensive linemen go down with injuries in their Week 3 win over the Arizona Cardinals according to head coach Kyle Shanahan who spoke with reporters Monday on a ...

The 49ers picked up a big road win on Sunday. Standout performances from San Francisco's 34-24 triumph over the New York Giants.

The San Francisco 49ers take on the Houston Texans at 10 a.m. PT on Sunday, Oct. 26 at NRG Stadium in Houston. The Niners are coming off consecutive games over NFC South contenders in the Buccaneers ...

As Maxx Crosby trade rumors make their way around the NFL, it was only natural that the San Francisco 49ers would get mentioned as a landing spot considering their pass rushing needs. Let’s get this ...

Explore the 49ers' quarterback updates, player injuries, and Robert Saleh's defensive tactics. Donnie and Joe preview the matchup ahead of Sunday's action. Opinion: Government shutdown showdown takes ...

A theme in the San Francisco 49ers' 30-19 loss to Tampa Bay in Sunday's NFL action was injuries. It turns out that even the players still on the field by the final whistle on Sunday were playing ...

KANSAS CITY, Mo. — The northbound lanes of Interstate 49, just south of Belton, Missouri, have re-opened following a deadly crash involving multiple cars, Tuesday. At about 2 p.m. Tuesday, the Cass ...

Christian McCaffrey and the San Francisco 49ers’ defense had a night. The star running back had 201 yards from scrimmage and two touchdowns as San Francisco topped the Atlanta Falcons, 20-10, on ...

San Francisco 49ers fans were treated to a concerning injury update regarding quarterback Brock Purdy during the Sunday Night Football broadcast of the team's game against the Falcons. The 25-year-old ...