The results suggest toxicity may not be as pervasive as previously thought, which argues for more-personalized monitoring.

Numerous studies have indicated that the plasma membrane plays an important role in the development of resistance to anthracycline and vinca alkaloid drugs (pleiotropic resistance). We have ...

EC-145 is a folate-targeted vinca alkaloid. Superiority of EC-145 with PLD over PLD alone was proven with respect to PFS (24.0 vs 11.7 weeks; HR: 0.497; p = 0.014).

Objectives Despite continued development of targeted therapies for children with cancer, patients continue to experience an array of unwanted side effects. Children with solid tumours may experience ...

Advancements in early detection and multimodal treatment strategies have significantly improved survival rates for early-stage breast cancer, now exceeding 80% at 10 years. However, breast cancer ...

The most common alkaloid found in the plants was lysergic acid alpha-hydroxyethylamide (LAH). This alkaloid is one of the lysergic acid amides Hofman identified in his studies.

In most cases, however, only the end product is known and it is largely unclear how these substances are produced in plants. Ipecacuanha alkaloids occur in two distantly related plant species ...

CIPN is a common, dose-limiting side-effect of chemotherapy use (132, 133) and is associated with a range of chemotherapeutic drug classes i.e. vinca alkaloids, platinum compounds, taxanes, ...

Nine new alkaloids, melodinines M–U (1–9), and 11 known alkaloids were isolated from Melodinus suaveolens. The new structures were elucidated by extensive NMR and mass spectroscopic analyses and ...