Cleveland Guardians first baseman Carlos Santana was scratched from the lineup against the Detroit Tigers with tightness in his left leg.

These two franchises have played more than 2,300 games against each other in history, with each owning identical win totals.

The Cleveland Guardians (29-22) look to complete a 4-game sweep at the Detroit Tigers (33-20) Sunday. First pitch from Comerica Park is set for 11:35 a.m. ET (Roku). Let's analyze BetMGM Sportsbook's MLB odds around the Guardians vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

In this exciting MLB matchup, the Cleveland Guardians will face the Detroit Tigers on Saturday night at Comerica Park, and you can catch all the action with Fubo.

It felt like the Tigers were waiting around to die Saturday night. Finally, in the 10th inning, the Guardians obliged them.

On Saturday, Cleveland won its fifth straight game against the Tigers between regular season and postseason play. Amazingly, the Guardians' 7–5 10-inning victory tied the all-time series at 1,161 games apiece. Sunday is the rubber match, and as all baseball fans know, the six best words in sports are Game Two Thousand Three Hundred Thirty-Five.

His 2.53 ERA in seven starts leads the Tigers' starting rotation, even better than reigning American League Cy Young winner Tarik Skubal's 2.87 ERA across 10 starts. Start the day smarter. Get all the news you need in your inbox each morning.

MLB player prop bets and odds for Riley Alan Greene on Saturday, May 24, 2025, as the Detroit Tigers take on the Cleveland Guardians.