Introduction Upadacitinib is a selective Janus kinase inhibitor (JAKi) licenced for use in patients with ulcerative colitis (UC) and is effective in inducing and maintaining remission in patients with ...

3 Department of Gastroenterology and Hepatology and Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden 4 Department of Gastroenterology and Hepatology, ...

Objective Pancreatic ductal adenocarcinomas (PDACs) include heterogeneous mixtures of low-grade cells forming pseudoglandular structures and compact nests of high-grade cells organised in ...

Objective To determine whether proton pump inhibitors (PPIs) are associated with an increased risk of colorectal cancer, compared with histamine-2 receptor antagonists (H2RAs). Design The United ...

Associate Prof. J E Kellow, Department of Medicine, Royal North Shore Hospital, St Leonards NSW 2065, Australia. Background—Life stress contributes to symptom onset and exacerbation in the majority of ...

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Conclusion Our ...

4 Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia Correspondence to Dr Hashem B El-Serag, Section of Gastroenterology and ...

Department of Surgery, Duke University Medical Center and Veterans’ Administration Hospital, Durham, NC, USA Correspondence to: Dr C R Mantyh, Duke University Medical Center, Box 3117, Durham, NC ...

Background Crohn's disease (CD) is a chronic disabling and progressive IBD. Only strategies looking beyond symptoms and based on tight monitoring of objective signs of inflammation such as mucosal ...

Correspondence to: Professor J Dent Department of Gastroenterology, Hepatology, and General Medicine, Level 7, North Wing, North Terrace, Royal Adelaide Hospital, Adelaide, South Australia 5000, ...

Background and aims Human telomerase reverse transcriptase (hTERT) plays an important role in cancer invasion, but the relevant mechanism is not well known. This study aims to investigate the role and ...

Correspondence to Dr James Lindsay, Barts Health NHS Trust, Endoscopy Unit, The Royal London Hospital, Whitechapel, London E1 1BB, UK; James.Lindsay{at}bartshealth.nhs.uk Objective Crohn's disease (CD ...