The San Francisco 49ers were handed their first division loss by the Rams on Sunday as a good showing by their offense wasn't nearly enough to offset a dreadful one by the defense.

Even though the odds of the San Francisco 49ers completing the comeback still would have been slim, Fox's officiating analyst said the referee crew's mistake late in Sunday's loss to the Rams took away a key first down.

The 49ers cannot afford for Purdy to be hurt long-term, which is probably why Shanahan has chosen instead to be cautious with the signal caller. The star quarterback might just need a couple more weeks to fully heal, which shouldn't be an issue for the team.

Here is where the San Francisco 49ers sit in the 2025 NFL Week 11 power rankings after their loss to the Los Angeles Rams.

Expert recap and game analysis of the Los Angeles Rams vs. San Francisco 49ers NFL game from November 9, 2025 on ESPN.

The Los Angeles Rams collected a 42-26 win on the road against NFC West rivals San Francisco 49ers on Sunday, but not before a worrisome injury development. In the fourth quarter of the contest, Los Angeles star wide receiver Davante Adams was seen leaving the field with an apparent upper-body injury.

The 49ers have been waiting for quarterback Brock Purdy to return from a toe injury for the last several weeks.