Two of Brock Purdy's worst performances in an otherwise stellar career came when he matched up against a Mike Macdonald-coached defense. Now thanks to one of his more memorable moments when he led the short-handed San Francisco 49ers to a fourth-quarter comeback in a wild-card win at Philadelphia,

This 49ers vs. Seahawks matchup is packed with star power on both sides of the ball. From elite playmakers to difference-makers in the trenches, these players have the biggest impact on how the game unfolds.